247 Drugs in Development

Drug Pipeline Tracker

Monitor breakthrough therapies from preclinical to FDA approval

8 Drugs in Pipeline

Last updated: 9/20/2025

IMB-7200

Immunoblade

Phase III

Indication

Severe Atopic Dermatitis

Mechanism of Action

JAK1 Selective Inhibitor

Superior Safety ProfileOral Administration
Expected Approval

Q1 2025

Trial Participants

800

Success Probability

81%

Market Opportunity

$3.3B

Last updated: November 14, 2024

BRX-1142

BrainRx Therapeutics

FDA Submitted

Indication

Treatment-Resistant Depression

Mechanism of Action

NMDA Receptor Modulator

PDUFA Date: March 2025Priority Review
Expected Approval

Q1 2025

Trial Participants

Completed

Success Probability

88%

Market Opportunity

$2.9B

Last updated: November 13, 2024

CAR-512

CellGen Bio

Phase II

Indication

B-Cell Acute Lymphoblastic Leukemia

Mechanism of Action

Next-Gen CAR-T Cell Therapy

90% Complete Response RateReduced CRS Risk
Expected Approval

Q1 2026

Trial Participants

150

Success Probability

72%

Market Opportunity

$2.1B

Last updated: November 12, 2024

ONX-4021

Onyx Therapeutics

Phase III

Indication

Non-Small Cell Lung Cancer

Mechanism of Action

PD-L1/VEGF Bispecific Antibody

Breakthrough Therapy DesignationFast Track Status
Expected Approval

Q2 2025

Trial Participants

1,200

Success Probability

68%

Market Opportunity

$4.2B

Last updated: November 10, 2024

ONC-3917

OncoNext

Phase I

Indication

Triple-Negative Breast Cancer

Mechanism of Action

TROP2-Directed ADC

Novel PayloadPromising Preclinical Data
Expected Approval

Q2 2027

Trial Participants

35

Success Probability

35%

Market Opportunity

$3.1B

Last updated: November 7, 2024

CVX-089

CardioVex

Phase III

Indication

Heart Failure with Preserved Ejection Fraction

Mechanism of Action

SGLT2/GLP-1 Dual Agonist

First Dual MechanismCardiovascular Outcomes Trial
Expected Approval

Q3 2025

Trial Participants

3,500

Success Probability

62%

Market Opportunity

$5.8B

Last updated: November 11, 2024

RDX-4729

Radix Pharmaceuticals

Phase II

Indication

Duchenne Muscular Dystrophy

Mechanism of Action

Gene Therapy (AAV-Microdystrophin)

Orphan Drug DesignationOne-Time Treatment
Expected Approval

Q3 2026

Trial Participants

48

Success Probability

58%

Market Opportunity

$1.5B

Last updated: November 5, 2024

NRX-101

NeuroRx Pharma

Phase III

Indication

Alzheimer's Disease (Early Stage)

Mechanism of Action

Tau Protein Aggregation Inhibitor

Novel MechanismPotential Disease Modification
Expected Approval

Q4 2025

Trial Participants

2,100

Success Probability

45%

Market Opportunity

$8.7B

Last updated: November 8, 2024

Pipeline Analytics

Key insights from our drug development tracker

68%

Average Phase III Success Rate

43

Expected Approvals 2025

$127B

Total Market Opportunity

18

Breakthrough Designations

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